May 7, 2024

EMDR and Ketamine Therapy: How Ketamine Therapy Can Enhance and Amplify the Effectiveness of EMDR

Eye Movement Desensitization and Reprocessing (EMDR) therapy and Ketamine therapy are two powerful therapeutic approaches that have shown promising results in treating various mental health conditions. While EMDR focuses on reprocessing traumatic memories, Ketamine therapy has been widely used to alleviate symptoms of depression, anxiety, and post-traumatic stress disorder (PTSD). In recent years, there has been growing interest in combining these two therapies to enhance and amplify their individual benefits. In this blog post, we will explore how Ketamine therapy can augment the effectiveness of EMDR and provide a deeper understanding of the potential synergies between these two modalities.

Understanding EMDR and Ketamine Therapy

EMDR therapy is a well-established treatment modality that aims to alleviate distress associated with traumatic experiences. It involves a series of structured protocols that guide the patient's attention while simultaneously engaging in bilateral stimulation, such as eye movements, tactile or auditory stimulation. By doing so, EMDR facilitates the reprocessing of traumatic memories, allowing the brain to heal and integrate the experience in a more adaptive manner.

Ketamine therapy, on the other hand, is a pharmacological treatment that utilizes the anesthetic and dissociative properties of ketamine to induce a unique state of consciousness. Traditionally used as an anesthetic, ketamine has demonstrated remarkable efficacy in treating mood disorders and PTSD when administered at sub-anesthetic doses. It is believed that ketamine's mechanism of action involves the modulation of glutamate receptors in the brain, leading to rapid synaptic changes and the promotion of neural plasticity.

The Synergy Between EMDR and Ketamine Therapy

  1. Enhanced Emotional Processing: EMDR and ketamine therapy both have the potential to enhance emotional processing. EMDR facilitates the integration of traumatic memories by stimulating the brain's information processing system. Ketamine, on the other hand, can weaken the emotional charge associated with traumatic memories, making them more accessible for reprocessing. When combined, these therapies may create a unique opportunity for individuals to engage with their traumatic memories in a less distressing and more adaptive manner.
  2. Increased Neuroplasticity: Ketamine therapy has been shown to enhance neuroplasticity, the brain's ability to reorganize and form new neural connections. By promoting neuroplasticity, ketamine can potentially facilitate the reprocessing of traumatic memories during EMDR sessions. This may lead to more efficient and lasting therapeutic outcomes, as the brain is better equipped to integrate and adapt to new experiences.
  3. Targeting Comorbid Symptoms: EMDR and ketamine therapy can be beneficial for individuals with comorbid symptoms, such as depression or anxiety, in addition to PTSD. Ketamine has shown rapid and significant antidepressant effects, which can alleviate symptoms of depression often associated with trauma. By reducing these comorbid symptoms, EMDR therapy can focus more effectively on reprocessing traumatic memories, leading to more comprehensive healing.
  4. Expanded Therapeutic Window: Some individuals with severe trauma may find it challenging to engage in EMDR therapy due to high levels of distress and hyperarousal. Ketamine therapy can help expand the therapeutic window by inducing a dissociative state that temporarily reduces the intensity of emotional and physiological responses to traumatic memories. This allows patients to engage in EMDR therapy more comfortably and effectively.

Ketamine therapy has been shown to increase the likelihood that an individual will successfully put together traumatic experiences in their mind.

Ketamine therapy has been shown to increase the likelihood that an individual will successfully put together traumatic experiences in their mind. This is because ketamine therapy works in a similar way to EMDR by engaging both sides of the brain through bilateral stimulation.

In addition, ketamine also helps individuals access their unconscious thoughts and feelings more readily, which can be useful when working with a therapist on issues related to trauma recovery.

Ketamine also boosts serotonin levels and increases glutamate transmission--both of which are important for healthy brain function and recovery from trauma or addiction (1).

In addition to these changes in your brain chemistry, ketamine can help you process traumatic memories more effectively by reducing activity in areas related to conscious awareness (2).

Ketamine therapy has also been shown to increase activity in the prefrontal cortex, which can help individuals recover from trauma by integrating their memories more effectively. The prefrontal cortex is an area of the brain that's involved in regulation and control of behavior and emotions. It helps us make decisions, plan for the future, think logically and solve problems creatively. This part of our brain also plays a role in processing memory--including traumatic ones--by integrating information into our long-term memory storage system so it can be accessed later (i.e., "Remembering what happened").

When used together, these treatments can be very effective in helping people heal from traumatic events and move forward with their lives.

Ketamine therapy can be used in conjunction with EMDR to help people recover from trauma. Ketamine therapy can help people integrate traumatic memories more effectively, which may then allow them to process those memories through EMDR more effectively.

EMDR is also known for reducing dissociation and helping patients feel less detached from their bodies and present in the here-and-now. This is why it's so important that you work with a therapist who specializes in both treatments--they'll know how best to combine them for maximum effectiveness!


Combining EMDR therapy and Ketamine therapy holds great potential for enhancing and amplifying the effectiveness of trauma treatment. By leveraging the benefits of both modalities, individuals can experience more profound healing, accelerated emotional processing, and improved overall well-being. While research in this area is still evolving, early findings and clinical experiences suggest that the integration of EMDR and Ketamine therapy can be a powerful tool in addressing the complex interplay between traumatic memories and mental health disorders. As with any therapeutic approach, it is essential for individuals to consult with qualified professionals to determine the most appropriate treatment plan tailored to their specific needs.


This blog is not medical advice or therapeutic advice but general knowledge to help you get the most out of your experiences with psychedelic therapy. At-home psychedelic therapy sessions with generic ketamine may be prescribed "off-label" for suitable candidates as an alternative pathway. Over the last two decades, research suggests that ketamine may be able to safely and effectively improve many treatment-resistant conditions. A form of ketamine, Esketamine (Spravato), is an FDA-approved medication for depression. Spravato treatments are only available in-person in our office. Our at-home programs include therapeutic guidance, safety protocols, breathwork, virtual treatment preparation and 1-on-1 integration coaching to get the most out of your sessions.