Antidepressant efficacy of ketamine

Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial

The authors evaluated the rapid antidepressant efficacy of ketamine in a large group of patients with treatment-resistant major depression. Ketamine demonstrated rapid antidepressant effects in an optimized study design, further supporting NMDA receptor modulation as a novel mechanism for accelerated improvement in severe and chronic forms of depression.

https://pubmed.ncbi.nlm.nih.gov/23982301/